健康大鼠经间歇性低氧训练后的心脏功能

Effect of interval hypoxic training on cardiac function of rats

背景:以往研究显示间歇低氧训练能够通过血液指标的改变提高有氧运动能力,但多集中于血液指标的研究,对心脏功能的影响少有报道。目的:通过对大鼠血流动力学指标进行测试,观察间歇性低氧训练对大鼠心脏功能的影响。方法:将雄性SD健康大鼠随机分为对照组、低氧组、运动组和运动低氧组。对照组自由活动和摄食,低氧组间歇性低氧训练,运动组进行无负重自由游泳训练。运动低氧组间歇性低氧复合运动训练,运动和低氧训练的方式和负荷安排同运动组和低氧组。正式训练4周后测试并比较各组心脏功能指标。结果与结论:4周训练结束后,3种干预模式对大鼠血流动力学指标均有不同程度的影响,其中运动低氧组左室最高收缩压、左室舒张末期压、等容舒张期左心室内压力下降速率、等容收缩期左室内压力最大上升速率、心指数指标均高于其他各组(P<0.05)。结果提示间歇性低氧复合运动训练可提高心脏收缩舒展功能。

BACKGROUND：Previous studies demonstrated that interval hypoxic training（IHT） can increase aerobic performance via altering blood index,but most of these are focus on researching blood index,the effects of IHT on cardiac function remain poorly understood.OBJECTIVE：To investigate the effect of IHT on the cardiac function by testing of hemodynamic parameters.METHODS：Female Sprague Dawley rats were randomly divided into the control,IHT,sports,and IHT ＋ sports groups.No treatment was performed on rats in the control group.IHT was performed in the IHT group.Rats were forced swimming without load in the sports group.In the IHT ＋ sports group,rats were forced IHT and sports.The cardiac functions of rats were tested at 4 weeks after training.RESULTS AND CONCLUSION：The hemodynamic parameters of rats were altered with different degrees in all groups exception of the control group.The left ventricle systolic pressure,left ventricle end-diastolic pressure,left ventricle the maximal rates of pressure fall,left ventricle the maximal rates of rise and cardiac index of the IHT ＋ sports group were higher than those of the other groups（P 0.05）.These findings revealed that IHT plus sport can increase cardiac systolic and diastolic functions.