血管紧张素转换酶抑制剂与心肌缺血再灌注的细胞凋亡

Angiotensin Converting-enzyme Inhibitors and Myocardial Apoptosis during Ischemia-reperfusion

随着心脏外科手术和介入治疗技术的进展以及心肌缺血患者的增加,心肌缺血再灌注损伤成为临床工作一种常见的病理生理过程。如何采用有效的治疗手段进行心肌保护,防治或降低缺血再灌注所造成的损伤,一直是心脏科学探索的一个重要课题。血管紧张素转化酶抑制剂对很多心脏疾病的治疗特别是拟行心脏手术患者的治疗都取得了良好的效果。随着对其研究的进展,其预处理可为临床预防治疗心肌缺血再灌注损伤提供思路与方法。

With the development of cardiac surgery, interventional therapy and the increase in myocardial ischemia patients, myocardial ischemia and reperfusion injury has become a common clinical pathophysiology. How to apply effective treatment for myocardial protection, prevention or reduction caused by ischemia- reperfusion injury, has been an important topic in the heart scientific exploration. Angiotensin-converting enzyme inhibitors have achieved good results on the treatment of many heart diseases, especially in cardiac surgery patients. With the progress of its research, the pretreatment clinical preventive treatment for myocardial ischemia reperfusion injury will provide ideas and methods.