上海市胃肠道间质瘤的临床调查及预后分析

Gastrointestinal stromal tumors ： epidemiological investigation and prognostic analysis in Shanghai

目的 研究上海市疾病控制中心（CDC）从 2003年1月1日至2008年12月31日登记的713例胃肠道间质瘤（GIST）的临床流行病学特征和预后因素. 方法 用描述性统计和生存分析中的log-rank检验和Cox模型对资料进行分析. 结果 肿瘤原发灶部位主要分布在胃419例（58.8%）、小肠203例（28.5%）、大肠58例（8.1%）,偶见于腹腔1例（0.14%）.COX生存分析显示性别、年龄、肿瘤原发部位、肿瘤分期以及不同的手术方式均是影响GIST预的相关因素. 结论 GIST预后的影响因素复杂,应结合实际作综合考虑.本研究提示老龄患者、晚期患者,以及未接受外科手术也是影响GIST患者预后的重要因素.因此对于GIST患者还是应以早发现,并首选外科根治手术治疗为根本措施.

Objective To investigate the clinical epidemiology characteristics and prognostic factors of 713 gastrointestinal stromal tumors （GIST） patients from Shanghai CDC＇s data bank for Shanghai tumor patient enrcgister during the period from January 1,2003 to December 31,2008. Methods Performed the descriptive statistics, log-rank test and Cox regression analysis. Results The tumor primary tumor site is mainly distributed in the stomach 419 cases （ 58.8% ） ; small bowel 203 cases （28.5%） ： colorectal 58 patients （8.1%）, occasionally in the abdominal cavity in 1 case （0.14%）. COX survival analysis showed age, sex, primary tumor site, tumor stage and different surgical methods are the relevant factors affecting the pre-GIST. Conclusion GIST prognosis of complex factors, should be integrated with the practical considerations, this study suggests that older patients, the terminally ill, and did not receive surgery that affects an important factor in the prognosis of GIST patients, it should be for GIST patients is still early detection, and the preferred surgical treatment of radical surgery as the fundamental measures.