bFGFR、COX-2和MVD在胃癌中的表达及其与浸润转移的关系

Expression of bFGFR,COX-2 and MVD and Their Relationships with Invasion and Metastasis in Gastric Cancer

目的探讨碱性成纤维生长因子受体(bFGFR)、环氧合酶-2(COX-2)和微血管密度(MVD)与胃癌浸润、转移的关系。方法选择80例手术切除的胃癌标本为观察组,40例慢性浅表性胃炎为对照组,应用免疫组织化学方法检测组织中bFGFR、COX-2和MVD的表达情况。结果 bFGFR及COX-2在胃癌患者中的阳性率为50.0%和52.5%。在对照组的阳性率分别为5.0%和0,差异均有统计学意义(P<0.01)。MVD在胃癌及对照组中的表达分别为(46.9±2.2)和(26.2±2.3),差异有统计学意义(P<0.01)。三者的表达与肿瘤的浸润、淋巴及远处转移呈正相关(P<0.01或P<0.05),与肿瘤大小、分化程度无关(P>0.05)。bFGFR阳性和COX-2阳性组MVD值(48.7±10.2、49.6±11.6)均高于bFGFR阴性和COX-2阴性组(33.6±5.2、32.7±4.5,P<0.01)。bFGFR与COX-2的表达呈正相关(γ=0.700,P=0.0000),二者在胃癌组织中的阳性表达强度与淋巴、远处转移呈正相关(P<0.01)。)结论胃癌组织中bFGFR、COX-2和MVD的表达与胃癌的浸润、转移密切相关,三者在肿瘤血管形成中可能存在相互协同作用。三者的阳性表达可作为胃癌生长,转移的重要判定指标。

Objective To investigate the expression of the basic fibroblast growth factor receptor（bFGFR）,COX-2 and MVD and their relationships with invasion and metastasis in gastric cancer.Methods Tissue sections from80 gastric cancer（GC）as experimental groups and tissue sections from40 chronic gastritis tissue as control groups were examined using immunohistochemistry for the expression of bFGFR,COX-2 and CD34.Results The positivity rates of bFGFR and COX-2 were 50.0% and 52.5%,respectively,which were significantly higher than those in patients with chronic gastritis tissue（P〈0.01）.The expression of MVD was（46.9±2.2）and（26.2±2.3）（P〈0.01）,respectively.The high positive expression of three indexes had correlation with regional invasion and lymphatic and remote metastasis in GC（P〈0.05）.But the expression has no correlation with the size and differentiation degree（P〉0.05）.The MVD values in bFGFR positive（48.7±10.2）and COX-2 positive（49.6±11.6）groups was significantly higher than those in bFGFR negative and COX-2 negative groups（33.6±5.2 and 32.7±4.5,P〈0.01）.The expression of bFGFR was significantly positively correlated with COX-2（γ=0.700,P=0.0000）.Conclusion The expression of bFGFR,COX-2 and MVD might be significantly correlated with invasion and metastasis of gastric cancer.The three indexes together may play coordinate role in vascularization.The positive expression of three indexes will be important diagnosis index in gastric cancer growth and metastasis.