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骨外骨肉瘤病理特征与鉴别诊断4例报道并文献复习 被引量:2

Pathology and Differential Diagnosis of Extraskeletal Osteosarcoma-Attached 4 Cases Report and Literatures Review
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摘要 目的探讨骨外骨肉瘤(extraskeletal osteosarcoma,EOS)的临床病理特征、免疫表型及病理诊断与鉴别诊断要点。方法收集4例EOS,对其临床、病理组织学及免疫表型进行观察并复习相关文献。结果 4例患者均为成年男性,平均年龄35.5岁。主要表现为无痛性或有触痛性软组织肿块。3例发生于下肢,1例发生于上肢。2例为肌纤维母细胞型EOS,1例为小细胞型EOS,1例为恶性纤维组织细胞型EOS。病理检查:(1)肉眼观见瘤体最大径平均为4cm,切面灰白,质软质脆,界限清楚。(2)镜检:肌纤维母细胞型EOS呈小叶状结构,细胞呈梭形或卵圆形。小细胞型EOS瘤细胞形态一致,弥漫分布。恶性纤维组织细胞型EOS瘤细胞多形性,伴多核巨细胞。(3)免疫组织化学:4例均表达Vim,OC,1例表达OCT。4例均不表达S100、desmin、CD34、NSE及SMA。结论 EOS是一种罕见的软组织肿瘤,其诊断主要依靠组织病理学特征,免疫组织化学标记可帮助诊断和鉴别诊断。 Objective To discuss the clinicopathologic characteristics,immunophenotype,pathologic diagnosis and differential diagnosis of extraskeletal osteosarcoma(EOS).Methods We collected extraskeletal osteosarcoma samples from4 EOS patients and observed the patients clinic characteristics,pathologic histology and immunophenotype,and then review the correlative literatures.Results The 4 patients are all male with an average age of 35.5 years old.They represented with soft lump without pain or tenderness.Three tumors located in low limbs,and 1 case in upper limbs.Two cases are myofibroblastic EOS,1 case is small cell type and the other case is MHF-like type.Pathology examination:(1)Grossly,the 4 tumors'average maximum diameter is 4 cm.Section shows gray,soft and crisp,and the boundary are clear.(2)Histologically,the myofibroblastic type presents lobular frame,and the tumor cells are spindle or oval.Small cell type shows diffuse identical cells.MHF-like type appear with pleomorphic cells companion multinucleated tumor giant cells.(3)Immunohistochemistry:The 4 cases tumor cells all express VIM(4/4),OC(4/4),and 1 case expresses OCT(1/4).S100,desmin,CD34,NSE and SMA are all negative in the 4 cases.Conclusions Extraskeletal osteosarcoma is a kind of rare soft issue tumor,and the mainly diagnosis evidence is the specific pathologic characteristics,and immunohistochemistry can assist diagnosis and differentiate diagnosis.
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2010年第9期1058-1061,共4页 Cancer Research on Prevention and Treatment
关键词 骨外骨肉瘤 诊断 鉴别诊断 免疫组织化学 Extraskeletal osteosarcoma Diagnosis Differential diagnosis Immunohistochemistry
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参考文献15

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共引文献12

同被引文献18

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