包埋式化疗泵治疗中晚期肺癌的临床研究

Clinical Study on Effectiveness and Method of Chemotherapy with Implantable Port System in Mid-advanced Pulmonary Carcinoma

目的建立一种对肺癌晚期病人的有效治疗方法,探讨与传统经静脉化疗相比运用包埋式化疗泵的效果及由此产生的并发症及化疗后对机体的影响情况。方法本研究以肺癌不能手术者为研究对象,分为两组,每组50例,包埋式化疗泵组(试验组)和静脉全身化疗组(对比组)。包埋式化疗泵组将化疗药物注入泵体。静脉全身化疗组将药品按常规方法配制后经静脉输入。结果试验组与对照组比较肿瘤缩小情况差异有统计学意义(P<0.05),试验组总有效率优于对照组。患者化疗后一般状态卡氏评分试验组与对照组比较差异有统计学意义(P<0.05),试验组优于对照组。白细胞化疗后7天及14天时试验组与对照组相比较差异有统计学意义(P<0.05)。CD4/CD8、NK细胞化疗后7天及14天时试验组与对照组相比较差异有统计学意义(P<0.05)。结论与传统的经静脉化疗相比,运用包埋式化疗泵缓慢灌注化疗其肿瘤缩小程度明显大于经静脉化疗组。化疗后患者的一般状态、白细胞减少情况、骨髓抑制及免疫功能情况均优于经静脉化疗组。

Objective To establish an effective treatment method of chemotherapy with implantable port system in pulmonary carcinoma to treat the patient with pulmonary carcinoma at the advanced stage.The effectiveness,complication and the influence on the patient of this method were comparatively studied with the traditional vein chemotherapy.Methods The pulmonary carcinoma patients were divided into two groups（50 patients per group）.In the experimental group,the chemotherapy medicine was injected into the pump body while the drugs were input by vein in the vein chemotherapy control group.Results The tumor size in the experimental group decreased more and showed significant difference（P〈0.05）from that in the control group.The general appearance after chemotherapy in the experimental group was better than that in the controlled group（P〈0.05）.The numbers of the white blood cells,the CD4/CD8 and the NK cells in the experimental and control groups showed significant difference（P〈0.05）after 7 and 14 days of treatments.Conclusion Compared with the traditional method,it was observed that the tumor sized decreased more,the general appearance became better and the decrease of white blood cells,CD4/CD8 and NK cells was lower in the method with implantable port system.