图形视网膜电图检测原发性开角型青光眼视网膜功能的意义

The significance of pattern electroretinogram in detecting retinal function in primary open angle glaucoma

目的观察原发性开角型青光眼（ｐｒｉｍａｒｙｏｐｅｎａｎｇｌｅｇｌａｕｃｏｍａ，ＰＯＡＧ）图形视网膜电图（ｐａｔｅｒｎｅｌｅｃｔｒｏｒｅｔｉｎｏｇｒａｍ，ＰＥＲＧ）的改变及其特点，了解ＰＥＲＧ在检测ＰＯＡＧ视网膜功能方面的意义。方法对３６例（５９只眼）ＰＯＡＧ及３２例（５９只眼）年龄相匹配的正常人进行ＰＥＲＧ检测。结果ＰＯＡＧ患者ＰＥＲＧ的ＡＰ１、ＡＮ２、ＡＮ２＋ＡＰ１、ＡＮ２／ＡＰ１下降；运用ＡＮ２＋ＡＰ１＜２７及ＡＮ２／ＡＰ１＜０７的方法，对已确诊的ＰＯＡＧ进行判别，阳性检出率为９０％；ＰＯＡＧ患者早期尚未发现视野改变前，ＰＥＲＧ振幅已有下降，其振幅随视野缺损的增大而降低；ＰＥＲＧ振幅与患者视力呈正相关，与视乳头杯盘比呈负相关，同时建立了回归方程。结论ＰＥＲＧ是检测ＰＯＡＧ视网膜功能状态的有效方法。

Objective To evaluate the clinical significance of pattern electroretinogram (PERG) in primary open angle glaucoma (POAG) Method Thirtysix patients (59 eyes) with POAG and 32 persons (59 eyes) as agematched normal controls were tested by PERG Results The changes of PERG in POAG included reduction of amplitudes of P1, N2, P1+N2 and N2/P1 Using the criteria of AN2+AP1<27 and AN2/AP1<07 (A = amplitude), the positive rate was 90% in 59 eyes with POAG, and no eye from the normal control group was considered as abnormal The amplitudes of PERG had already been abnormal before the early visual field loss occurred in POAG eyes The amplitudes of P1 and N2 waves decreased with the enlargement of visual field defect, were positively correlated to the patients visual acuity and negatively correlated to the cup/disc ratio of optic nerve papilla, and linear regression equations between them were respectively established Conclusion PERG is an useful method in detecting the retinal functions in POAG