高压氧治疗瓦斯中毒对纤维连接蛋白、血清白蛋白、三碘甲状腺原氨酸及甲状腺素的影响

Effects of HBO on fibronectin, serum albumin, T3 and T4 in patients with gas poisoning

目的 探讨高压氧（HBO）治疗急性瓦斯中毒的疗效,以及对血浆纤维连接蛋白（Fn）、血清白蛋白（PreA）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）的影响.方法 将76例患者分为轻度、中度、重度3组,采用大型空气加压舱进行HBO治疗,同时结合药物及抗感染治疗;治疗前后分别测定血浆Fn含量以及血清PreA、T3和T4含量,并进行比较.结果 76例急性瓦斯中毒患者,治愈58例,显效14例,好转4例;3组患者治疗前血浆Fn含量与正常组（32名健康献血者）比较差异有统计学意义（P〈0.01）,治疗后血浆Fn含量与正常组比较差异有统计学意义（P〈0.05）;血清PreA、T3、T4治疗前后与正常组比较均无统计学差异（P〉0.05）.结论 HBO治疗急性瓦斯中毒患者疗效显著,HBO对急性瓦斯中毒患者血浆Fn含量影响明显,对血清PreA、T3、T4含量影响不大.说明HBO治疗在促进急性瓦斯中毒患者机体Fn自主恢复方面具有重要意义,但其机制有待进一步研究.

Objective To explore the effect of HBO on acute gas poisoning and also its effects on fibronectin, serum albumin, T3 and T4 in these patients. Methods Seventy-six cases were divided into 3 groups： the mild, the moderate and the severe groups. All the patients were treated with HBO in large air compression chamber, and were also given anti - infection and other drug treatment. Levels of plasma fibronectin, serum albumin, T3 and T4 were determined and compared both before and after treatment. Results Of the 76 patients with acute gas poisoning, 58 cases were cured, 14 cases responded very effectively and 4 cases improved. Statistical differences could be seen in the contents of plasma Fn measured before treatment for the 3 groups, when they were compared with those of the normal group （32 healthy donors） （P 〈 0. 01）.Significant differences could also be noted in the contents of Fn measured after treatment, when a comparison was made between of the groups （P 〈0.05）. And no statistical differences could be seen in the levels of serum albumin both before and after treatment, when compared with those of the normal group （P 〈 0. 05）.Conclusions Experiments showed that HBO could produce significant effect on patients with acute gas poisoning. HBO had obvious effect on the content of plasma Fn, while little effect could be seen in serum albumin,T3 and T4 in patients with acute gas poisoning. It might indicate that HBO played an important role in the autonomous recovery of Fn in patients with acute gas poisoning. However its mechanism remained to be explored.