急性淋巴细胞白血病患儿SF及β2-MG检测的临床意义

Clinical Significance of Serum Ferritin and β2-MG Detection in Children with Acute Lymphoblastic Leukemia

目的观察急性淋巴细胞白血病(ALL)患儿血清铁蛋白(SF)及β2-微球蛋白(β2-MG)水平变化,探讨SF和β2-MG水平变化对ALL患儿临床治疗效果的应用价值。方法对2008年7月-2010年4月期间血液病区住院确诊为ALL的患儿53例,病情得到控制缓解后的ALL患儿28例,分别抽取空腹静脉血进行SF和β2-MG测定,并选取正常健康儿童30例作为对照组。结果 ALL患儿治疗前血清SF和β2-MG水平均高于正常对照组(P<0.01),经治疗缓解后ALL患儿的SF和β2-MG水平显著降低,并随着病情的转归而逐渐恢复至正常水平;与治疗前比较,差异有统计学意义(P<0.01)。结论 SF和β2-MG可作为ALL临床治疗效果的有效监测指标。

Objective To observe the dynamic changes of Serum Ferritin（ SF） and β2-MG levels in children with acute lymphoblastic leukemia（ ALL） and to investigate its clinical significance on clinical curative effect. Methods Fifty-three in-patients with ALL,28 relieved patients from July 2008 to April 2010 in our Hematology and 30 normal as control were selected in our study. The venousblood of patients and controls were extract in order to detect SF and β2-MG. Results Before the treatment,the level of SF and β2-MG in ALL group were significantly higher than those in the control group （ P 〈0. 01）. After the treatment,the level of SF and β2-MG in ALL group decreased significantly （ P 〈0. 01） ,and they return to normal level gradually with the outcome; compared with before the treatment,the differences were statistically significant（ P 〈0. 01）. Conclusion SF and β2-MG can be used as a helpful indicator to evaluate the therapeutic effect of ALL.