摘要
血管的零应力状态的变化是反映血管组织非均匀改造的一个简明参量。本文研究了血栓形成后血管零应力状态的变化。血栓模型采用机械损伤大鼠腹主动脉内膜同时造成远段狭窄的办法建立，成功率为７８４％，血栓平均长度为８５～１．４ｍｍ。取下血栓形成部位的血管，观察其零应力状态，测量其张开角。结果显示血栓形成后腹主动脉的张开角明显降低（５６３±１０９°），明显低于对照组（１２９．２±３３．５°）。本实验结果表明血栓形成可引起血管壁的非均匀组织改造。
Effect of thrombosis on zerostress state of artery was tested by using an animal thrombosis model. The thrombosis was induced in rat abdominal aorta by endothelium denudation with a polyethylene catheter together with severe stenosis due to aortic constriction. The thrombosis rate was 78%, and the length of thrombi was 8.51.4mm. The opening angles at zerostress state of abdominal aorta were measured. Results showed the opening angel of thrombotic artery (56.310.9) was significantly smaller than the control group (129.233.5) and the heparin group (146.234.1). This indicated that nonuniform histological changes occurred in vessel due to thrombosis.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
1999年第2期184-186,210,共4页
Chinese Journal of Biomedical Engineering
基金
日本心血管研究基金会(韩)资助
国家教委优秀年轻教师基金
