摘要
采用Ｗ／Ｏ／Ｗ型复乳制备聚原酸酯载甲氨喋呤（ＭＴＸ）毫微囊微球，通过多种条件实验，制备了聚原酸酯载药毫微囊，并对药物体外释放动力学进行研究。结果表明有机溶剂组成、内部水相药物浓度、溶剂挥发温度等均对毫微囊的结构与性能产生影响，经优化所制备毫微囊粒径在５００～８００ｎｍ之间，药物包封率高。
Anticancer drug loaded poly (ortho esters) nanocapsules were prepared using a doubleemulsification/solvent evaporation technique. The release characters and the affect factors were studied. The POE nanocapsules were regular in morphology with a mean diameter of 500800nm. The drug loaded ratio was about 30%. By using certain mixture solvent, drug concentration and lower evaporation temperature, the satisfactory nanocapsules can be obtained.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
1999年第2期216-221,共6页
Chinese Journal of Biomedical Engineering
关键词
聚原酸酯
载药毫微囊
抗癌药
体外释药
Poly (ortho esters)
Nanocapsules
Controlled release
Anticancer drugs
