肺心病血内皮素-1和一氧化氮含量变化

A Study on Changes of Plasma Endothelin 1 and Serum Nitric Oxide in Patients with Chronic Pulmonary Heart Disease.

用放射免疫分析法及分光光度比色法测定３０例肺心病人血内皮素１（ＥＴ１）和一氧化氮（ＮＯ）含量及两者比值（ＥＴ１／ＮＯ）。治疗前肺心病患者ＥＴ１明显高于正常人，ＮＯ则低于正常人，均Ｐ＜００１，ＥＴ１／ＮＯ比正常人高（Ｐ＜００１）；治疗后，ＥＴ１显著降低，但仍高于正常人（Ｐ＜００１），ＮＯ无明显变化（Ｐ＞００５），ＥＴ１／ＮＯ与正常人比较仍存在差异（Ｐ＜００１）。表明肺心病治疗前后均有ＥＴ１和ＮＯ失衡。提示ＥＴ１，ＮＯ含量及比值变化与肺心病病理改变有关。

Plasma Endothelin 1(ET 1) and serum nitric oxide(NO) were measured by radioimmunuassay(RIA) and spectrophotometric techniques in patients with cor pulmonale(group A). The results showed as follows:ET 1 was greatly higher before treatment in group A than that in control, NO was reversed(P<0 01). ET 1/NO was also higher in group A than that in control. After treatment, however, ET 1 was significantly decreased, but still higher than that in control(P<0 01), NO had no obvious change while ET 1/NO was also in a high level when compared with that in control. It is indicated that an imbalance always exist between ET 1 and NO in patients with cor pulmonale before and after treatment, which suggests that changes of ET 1 and NO are related to the pathophysiological process of cor pulmonale.