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调节钙粘蛋白抑制肿瘤转移药物的新进展 被引量:1

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摘要 肿瘤细胞向周围基质渗透进入淋巴管及血管,向其他器官或组织转移,是肿瘤重要的生物学特征之一。目前,肿瘤的治疗方法虽然已有显著提高,但诊断为癌症晚期的患者大多数因肿瘤转移的发生而死亡。因此,抑制肿瘤转移对癌症患者的治疗具有重要意义。研究发现,肿瘤转移与细胞自身粘附能力的改变密切相关。改变细胞粘附抑制肿瘤转移的药物,可望成为肿瘤治疗的新选择。
出处 《中国药师》 CAS 2010年第10期1425-1427,共3页 China Pharmacist
基金 福建省自然科学基金(2008J0103) 南京军区医学科学技术研究"十一五"计划课题(06MA154)
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  • 1Lee JJ,Lotze MT, Molecular basis of metastasis[ J]. N Engl J Med,2009,360 (16) :1679.
  • 2Iiizuml M, Liu W, Pai SK, et al. Drug development against metastasis-related genes and their pathways : a rationale for cancer therapy [ J ]. Biochim Biophys Aeta,2008,1786( 2 ) :87-104.
  • 3Gloushankova NA. Changes in regulation of cell-cell adhesion during tumor transformation [ J ]. Biochemistry (Mosc ), 2008,73 ( 7 ) : 742 -750.
  • 4Wallerand H, Cai Y, Wainberg ZA, et al. Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines [ J ]. Urol 0ncol,2008,28 (2) : 180-188.
  • 5Hazan RB, Qiao R, Keren R, et al. Cadherin switch in tumor progression [ J ]. Ann N Y Acad Sci ,2004,1014 : 155-163.
  • 6Wheelock M J, Shintani Y, Maeda M, et al. Cadhefin switching [ J ]. J Cell Sci, 2008,121 ( Pt 6) :727-735.
  • 7Jiao W, Miyazaki K, Kitajima Y. Inverse correlation between E--cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo[ J]. Br J Cancer,2002,86( 1 ) :98-101.
  • 8Grunhage F, Jungck M, Lamberti C, et al. Association of familial colorectal cancer with variants in the E-cadherin ( CDH1 ) and eyclin D1 ( CCNDI ) genes[J ]. lnt J Colorectal Dis,2008,23(2) :147-154.
  • 9Luan FL,Ding R,Sharma VK,et al. Rapamycin is an effective inhibitor of human renal cancer metastasis[J]. Kidney Int ,2003 ,63 ( 3 ) :917-926.
  • 10vander Poel HG. Mammalian target of rapamycin and 3-phosphatidylinosital 3- kinase pathway inhibition enhances growth inhibition of transforming growth factor-beta1 in prostate cancer cells[ J]. J Urol,2004,172(4 Pt 1) :1333-1337.

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