加味愈白丸对实验性白癜风模型豚鼠的治疗作用

Treatment Effects of Jiawei Yubai Pills on Vitiligo Model of Experimental Guinea Pig

目的:研究加味愈白丸对实验性白癜风模型豚鼠的治疗作用,为临床用药提供依据。方法:采用氢醌脱色法制备实验性白癜风豚鼠模型,观察加味愈白丸低、中、高剂量组及阳性对照组对实验性白癜风模型豚鼠血液中酪氨酸酶、单胺氧化酶(MAO)、胆碱酯酶(CHE)和丙二醛(MDA)、免疫器官脏器系数、血液流变学各项指标以及皮肤黑色素的影响。结果:加味愈白丸能够使模型豚鼠血浆中酪氨酸酶含量明显增多,MAO值降低,CHE活力降低,MDA含量减少,免疫功能增强,血液粘稠度降低以及皮肤黑色素的生成增加。结论:加味愈白丸对实验性白癜风模型豚鼠有一定的治疗作用。

Objective ： To provide the evidence for clinic usage through studing jiawei yubai pills in treatment of vitiligo model in experimental guinea pig. Method： The experimental guinea pig model of vitiligo was induced by hydroquinone bleaching. The tyrosinase,monoamine oxidase （MAO） ,cholinesterase （CHE） ,malondialdehyde （MDA） ,immune organ index,hemorheology indicators and skin melaninin were observated in bloold of each experimental guinea pig with low dosage, medium dosage, high dosage of jiawei yubai pills and positive control group to detect the effect of jiawei yubai pills on vitiligo. Result： Jiawei yubai pills had significantly increased the level of tyrosinase in plasma of modeling guinea pig, decreased levels of MAO, CHE, MDA in serum of modeling guinea pig, increased the immunity of modeling guinea pig, decreased the blood viscosity of modeling guinea pig, and increased skin melanin. Conclusion： Jiawei yubai pill has a therapeutic effect on experimental guinea pig model of vitiligo.