锡类散栓剂治疗大鼠溃疡性结肠炎的实验研究

Experimental study on rats with ulcerative colitis in traditional Chinese medicine suppositories

目的 观察自制锡类散栓对大鼠实验性溃疡性结肠炎的疗效。方法 用免疫学方法制造溃疡性结肠炎大鼠模型，实验鼠随机分为４ 组：锡类散栓剂组（ Ａ 组） ；柳氮磺胺吡啶（ Ｓ Ａ Ｓ Ｐ） 栓剂组（ Ｂ 组） ；基质栓剂组（ Ｃ 组） ；空白对照组（ Ｄ 组） 。前３ 组各予中药栓、 Ｓ Ａ Ｓ Ｐ栓及基质栓塞肛，连用２ 周， Ｄ 组不作处理。第１６ 天处死大鼠，作结肠粘膜 Ｓ Ｏ Ｄ 活性测定及病理检查。结果 病理结果显示 Ａ、 Ｂ组治疗效果相仿，其结肠粘膜仅有充血水肿，明显好于 Ｃ组； Ｃ 组仍有糜烂及溃疡。 Ｓ Ｏ Ｄ 活性： Ａ 组明显高于其他组，差异有显著意义（ Ｐ＜ ０ ．０１） ， Ｂ组与 Ｃ、 Ｄ 组比较无明显差异（ Ｐ＞ ０ ．０５） 。结论 自制锡类散栓对大鼠溃疡性结肠炎有较好的治疗作用，其作用机制可能是通过提高肠粘膜内 Ｓ Ｏ Ｄ 活性而实现的。

Objective To observe the therapeutic effect of the suppositories made of traditional Chinese medicine to experimental rats with ulcerative colitis.Methods Having been made by using immunological method,all these rats model were randomly divided into four groups:group A,B,C,D.They received traditional Chinese medicine suppositories,salfasalazine suppositories,and base suppositories once a day for 2 weeks in group A,B,C and nothing in group D respectively.Mucosal SOD activity and histopathology were assessed.Results The efficacy of the rats in group A,B were better than that in group C.An increased SOD activity were found in group A.There were distinct difference compared SOD value of group A with that of other groups ( P <0.01).difference of SOD value was not found between group B and group C,D ( P >0.05).Conclusion Traditional Chinese suppositories designed and made by us were effective for rats ulcerative colitis.The mechanism of the medicine is achieved possibly through improving SOD activities within intestinal mucosa and can be a therapeutic drug used to adequate patients in future.