摘要
目的探讨帕罗西汀联合认知疗法治疗抑郁症的临床疗效。方法将90例抑郁症患者随机分为研究组与对照组各45例,两组均口服帕罗西汀治疗,研究组在此基础上联合认知心理治疗。观察8周。于治疗前及治疗第2、4、8周末采用汉密尔顿抑郁量表(HAM D)及副反应量表(TESS)评定临床疗效和不良反应。出院后随访1年,统计复发率。结果治疗8周末,研究组有效率95.6%,对照组为82.2%,两组比较差异有显著性(χ2=4.05,P<0.05)。治疗2周末起,两组汉密尔顿抑郁量表总分均较治疗前有显著下降(t=9.627和6.439,P<0.01),研究组治疗2周末起较对照组下降更显著(t=1.766,P<0.05)。随访1年末研究组复发率15.5%,对照组为33.3%,研究组复发率显著低于对照组(χ2=3.85,P<0.05)。结论帕罗西汀联合认知心理治疗能显著提高抑郁症的临床疗效,有效预防复发,改善预后。
Objective To explore the efficacy of paroxitine combined with cognitive therepy in the treatment of depression.Methods A total of 90 depression patients were randomly dividid into study and control group(each n=45),both groups took orally paroxitine,research group plused cognitive therapy for 8 weeks.Efficacies were assessed with the Hamilton Depression Scale(HAMD) before treatment and at the end of the 2nd,4th and 8th week treatment and adverse reactions with Treatment Emergent Symptom Scale(TESS).They were followed up for 1 year after discharge,relapse rates were added up.Results At the end of the 8th week,effective rates were respectively 95.6% in study and 82.2% in control group,the former was significantly higher than the latter(χ2=4.05,P0.05).Since the end of the 2nd week,total scores of the HAMD of both groups lowered more significantly compared with prreatment(t=9.627 and 6.439,P0.01);At the end of the 2nd week,those did more significantly in study than in control group(t=1.766,P0.05).Incidence of adverse reactions were significantly lower in study than in control group(15.5% vs 33.3%,χ2=3.85,P0.05) at the end of 1 year follow-up.Conclusion Paroxitine combined with cognitive therapy can improve the curative effect in the treatment of depression.and effectively prevent relapse and improve prognosis.
出处
《中国健康心理学杂志》
2010年第9期1031-1032,共2页
China Journal of Health Psychology