阿立哌唑与利培酮治疗老年期精神分裂症的对照研究

Comparison Study on Aripiprazole and Risperidone in Treatment of Aged Schizophrennia

目的比较阿立哌唑与利培酮对老年期精神分裂症的疗效和不良反应。方法将60例老年期精神分裂症患者随机分为阿立哌唑组和利培酮组,分别给予阿立哌唑与利培酮治疗,疗程8周。采用阳性和阴性症状量表(PAN SS),副反应量表(TESS)评定疗效和不良反应。结果阿立哌唑组显效率46.7%,有效率83.3%,利培酮组显效率50.0%,有效率86.7%,两组疗效相仿,阿立哌唑组锥体外系反应小于利培酮组,但起效较利培酮组慢。结论阿立哌唑治疗老年期精神分裂症疗效与利培酮相仿,不良反应较轻,依从性好,值得推广。

Objective To compare the efficacy and adverse effect respectively of Aripiprazole and Risperidone in treatment of aged patients with schizophrennia.Methods A total of 60 patients were randomly divided into two groups,which were treated with Aripiprazole or Risperidone respectively for 8 weeks.The Positive and Negative Syndrome Scale（PANSS）and Treamnent Emergent Side Effect Scale（TESS） were used to evaluate the efficacy and adverse effect respectively.Results The effective and effectual rates of Aripiprazole were 46.7% and 83.3%,The effective and effectual rates of risperidone were 50.0% and 86.7%.There was no significant difference in clinical efficacy between two groups.The incidences of extra-pyramidal symptoms in Aripiprazole group was lower than those in Risperidone group.Aripiprazole could take into effect slowly than Risperidone.Conclusion Aripiprazole is as effective as Risperidone on aged schizophrennia with milder side effects and better patients＇ compliance,and deserves to be clinically popularized.