52例轻中度高血压患者动态血压与尿微量蛋白检测的相关分析

Correlation between the Ambulatory Blood Pressure and Examination of Minimal Urinoproteins in Patients with Mild to Moderate Essential Hypertension

目的：探讨动态血压与尿微量蛋白和高血压患者肾受累的关系。方法：对５２ 例轻中度高血压病（ＥＨ）患者和３０ 例正常人进行２４ ｈ 动态血压监测（ＡＢＰＭ），同时用放射免疫法测定其尿微量白蛋白（Ｍ－ＡＬＢ）、α１ －微球蛋白（α１－ＭＧ）、β２ －微球蛋白（β２－ＭＧ），并对两组参数进行相关性分析。结果：ＥＨ 组尿Ｍ－ＡＬＢ明显高于对照组（Ｐ＜０．０５）。ＡＢＰＭ 显示ＥＨ组Ｍ－ＡＬＢ与日间、夜间的收缩压（ＳＢＰ）及其负荷值和２４ ｈ ＳＢＰ负荷值有相关性（ｒ＝ ０．３１～０．３８，Ｐ＜ ０．０５～０．０１）。结论：Ｍ－ＡＬＢ可作为ＥＨ患者肾脏早期受损的一个指标。ＡＢＰＭ 在评价ＥＨ肾脏靶器官损害方面有较好的预测价值。

Objective: To investigate the correlations between renal impairment and ambulatory blood pressure (ABP) and the urine microprotein. Methods: ABP monitoring was performed and microalbuminuria (M ALB)\, α 1 microglobulin (α 1 MG)\, β 2 microglobulin(β 2 MG) in urine were determined by radioimmunoassay in 52 patients with mild to moderate essential hypertension and 30 normotensives. Results: The M ALB level in hypertensive group was higher than that in the normotensive group (P<0.05). The ABPM showed that the M ALB in hypertensive group was closely related to the day and night systolic blood pressure (SBP) and their load values, and it also related to the load value of 24 hour SBP (r=0.31~0.38, P<0.05~0.01). Conclusion: M ALB may be an useful index for evaluation of earlier renal damage, ABPM is superior to the casual BP in predicting renal target organ involvement.