肝动脉栓塞加肝门静脉灌注双重化疗治疗无手术指征肝癌的临床研究

Clinical Research of the Treatment in Late Liver Carcinoma by both Emobolism of Hepatic Artery and by Double Chemotherapy into Hepatic Artery and Portal Vein

目的：研究一种治疗晚期肝癌的新方法。方法：４９ 例无手术指征肝癌患者，行单纯肝动脉栓塞与在肝动脉栓塞的基础上行肝门静脉化疗的对照研究。结果：通过双重化疗后，使无手术指征肝癌的平均生存月数提高到２１．４７ 个月，从而使无手术指征肝癌患者的半年生存率达１００％ ；１ 年生存率达７６．５％ ，２ 年生存率达３５．２９％ ，３ 年生存率达２３．５３％ ，并且使肝癌全身转移的发生率明显下降，而无明显的治疗后副作用。结论：双重化疗是一种能明显提高无手术指征肝癌患者生存期的有效的、安全的治疗方法。

Objective: To study a new method in the treatment of late liver carcinoma. Methods: 49 patients with late liver carcinoma were treated with embolism of hepatic artery and combined with chemotherapy through portal vein were reported. Results: The result showed that double chemotherapy in hepatic artery and portal vein can prolong the mean survival of the patients up to 21. 47 months. The patient's half year , one year , two year and three year survival rates were 100%, 76.5%, 35. 29% and 23. 53%, respectively. And this method can also decrease the rate of metastasis. No remarkable complications werefound after the treatment. Conclusion: The double chemtherapy is an effective and safe way in treating the.patients of late liver carcinoma.