29例髓母细胞瘤术后放射治疗

Postoperative Radiotherapy for 29 Cases of Medulloblastoma

目的：回顾２９ 例髓母细胞瘤术后放疗，对影响生存情况的因素进行分析。方法：手术后病理证实的２９例髓母细胞瘤，先行卡氮芥（ＢＣＮＵ）化疗，再行６０钴常规分割照射：全脑剂量（ＤＴ）２２～４０ Ｇｙ；原发病灶追加ＤＴ１５～２２ Ｇｙ；全脊髓轴ＤＴ２５～３５ Ｇｙ。结果：１、３、５、８ 年生存率分别为８９．６％ （２６／２９）、５５．２％ （１６／２９）、３０．４％ （７／２３）、２５．０％ （４／１６）。结论：病人生存期长短与手术切除范围、术后接受放疗时间、放射剂量及是否行化疗有关。

Objective: The results of radiotherapy for 29 cases of medulloblastoma were reviewed retrospectively. Methods: 29 medulloblastoma were proved by pathohistology postoperatively. Most cases accepted postoperative chemotheapy with BCNU, then radiotherapy, the doses of overall brain were 22~40 Gy boosted to tumor bed, using conventional fraction, 25~35 Gy and 15~22 Gy boosted to tumor bed, using conventional fraction, 25~35 Gy were given to spinal cord. Results: The 1 year, 3 year, 5 year, 8 year survival rates of these were 89.6%(26/29), 55.2%(16/29), 30.4%(7/23), 25.0%(4/16). Conclusion: The survival time was related to tumor's resection, period of postoperative radiation, radiation dose and chemotherapy.