小分子葡萄糖激酶激动剂的研究进展

Advances in the Study of Small Molecule Glucokinase Activators

葡萄糖激酶是糖代谢途径中的关键酶,能够同时作用于肝脏与胰岛B细胞而具有促进肝糖原生成及促进胰岛素分泌的作用。近年来以其为靶点的新型降糖药物研究活跃,部分小分子化合物已进入临床试验阶段,其他结构化合物也在动物模型研究中证实具有降糖活性。以葡萄糖激酶为靶点,寻找其激动剂的新型降糖药物具有广阔的前景。

Glucokinase plays an important role in glucose homeostasis, which promotes glycogen synthesis in the liver and upregulates insulin secretion in the pancreatic B-cells. In recent years, several glucokinase activators have been developed, some of which are in clinical trials, and experimental studies show that other compounds about glucokinase activators have antidiabetic activity. These researches demonstrate glucokinasc activators represent a promising new treatment for type 2 diabetes.