内源性哇巴因在原发性肾病综合征发病中的作用

THE ROLE OF ENDOGENOUS OUABAIN ON DEVELOPMENTOF PRIMARY NEPHROTIC SYNDROME

采用敏感性、特异性均较高的特异性抗哇巴因抗体酶联免疫吸附法（ＥＬＩＳＡ法）对２０例肾功正常的原发性肾病综合征患者血清内源性哇巴因（Ｅｎｄｏｇｅ－ｎｏｕｓｏｕａｂａｉｎ，ＥＯ）水平进行测定。发现肾功正常的原发性肾病综合征患者血清ＥＯ水平显著高于正常对照组，有高血压的肾病综合征患者血清ＥＯ水平显著高于无高血压组。结果表明ＥＯ在原发性肾病综合征的发生发展及肾性高血压的产生和维持中起一定作用。

The serum endogenous ouabain (EO) level of 20 primary nephrotic syndrome patients with normal renal function were measured by sensitivity and specificity enzyme linked immunoassay (ELISA).We found that the serum EO level of primary nephrotic syndrome was markedly higher than that of normal subjects, the serum EO level of primary nephrotic syndrome with hypertension was markedly higher than those without hypertension.The results indicates that EO play an important role on development of primary nephrotic syndrome and nephrotic hypertension.