罗库溴铵预注效果的临床研究

Assessment of the Effects of Priming Rocuronium

目的：研究罗库溴铵的预注效果。方法：ＡＳＡⅠ～Ⅱ级择期全麻手术４６例，男２５例，女２１例，分为三组。Ⅰ组（ｎ＝１８）用罗库溴铵预注法诱导插管，应用正交试验Ｌ（３７）方法，观察００４５、００６、００７５ｍｇ／ｋｇ三种不同水平的预注量（ＰＤ），２、３、４分钟预注时间（ＰＩ）及０３、０４５、０６ｍｇ／ｋｇ插管剂量（ＩＤ）对预注效果的影响；Ⅱ组（ｎ＝１８）用罗库溴铵０３、０４５、０６ｍｇ／ｋｇ常规诱导插管；Ⅲ组（ｎ＝１０）用琥珀胆碱１ｍｇ／ｋｇ诱导插管。结果：预注效果明显（Ｐ＜００５），ＩＤ和ＰＤ是决定起效时间的主要因素（Ｐ＜００５），ＰＩ不明显（Ｐ＝０４５）。结论：ＰＤ００６ｍｇ／ｋｇ、ＰＩ２分钟、ＩＤ０６ｍｇ／ｋｇ是罗库溴铵预注的较好模式。

Objectives: The study was designed to assess the effects of priming rocuronium on the onset time under general anesthesia. Methods: The effects of three priming doses of rocuronium (PD:0045,006or0075mg/kg), priming intervals (PI:2,3 or4 min) and intubation doses (ID:03,045 or 06mg/kg) were observed using orthogonal design in 18 patients. Other 18 patients received conventional induction with 045,06 or 075mg/kg of rocuronium and 10 patients received 1mg/kg of suxamethonium as control. Results: The effects of priming rocuronium was evident (P<005), ID and PD were important factors. Conclusion: PD006mg/kg, PI 2min and ID06mg/kg might be reasonable mode of priming rocuronium.