双模式分子影像探针研究进展

The research progress of dual-modality probes for molecular imaging

许多影像模式能应用于体内组织的解剖或功能成像.然而,每种影像模式都有自己的优缺点,目前还没有一种单纯模式能同时提供全部的解剖、功能以及分子信息.联合使用两种不同的影像模式,将大大提高影像诊断及治疗的能力.随着越来越多的双模式影像系统出现,人们对双模式探针的研究已经取得了很大的进展,这些双模式探针能充分发挥每种影像模式的优势,已经成为未来多模式影像的新工具,为临床诊断提供全面的信息.该文讨论了双模式影像探针的研究进展及其面临的挑战.

Various imaging modalities have been exploited to investigate the anatomic or functional dissemination of tissues in the body. However, no single imaging modality allows overall structural,functional, and molecular information as each imaging modality has its own unique strengths and weaknesses. The combination of two imaging modalities that investigates the strengths of different methods might offer the prospect of improved diagnostic abilities. As more and more dual-modality imaging system have become clinically adopted, significant progress has been made toward the creation of dual-modality imaging probes, which can be used as novel tools for future multimodality systems. These all-in-one probes take full advantage of two different imaging modalities and could provide comprehensive information for clinical diagnostics. This review discusses the advantages and challenges in developing dual-modality imaging probes.