肿瘤血管内皮生长因子受体核素显像研究现状

Review present study on vascular endothelial growth factor receptor imaging

肿瘤血管生成是肿瘤生长与转移生物学行为的重要基础.血管内皮生长因子（VEGF）及共受体（VEGFR）在肿瘤血管生成过程中起到了关键性的作用.VEGFR已成为目前肿瘤血管生成的诊断和治疗研究领域具有潜在应用价值的分子靶点.放射性核素受体显像具有灵敏度高、特异性强的优点,能够客观、准确显示体内肿瘤组织VEGFR的分布、密度及与其配体的结合亲和力,有助于肿瘤的诊断与鉴别诊断、临床分期、复发与转移的探测,并对临床实施针对VEGFR的肿瘤生物治疗具有积极的指导作用.

Tumor angiogenesis is the foundation of tumor growth and metastasis. The vascular endothelial growth factor （VEGF） and VEGF receptor （VEGFR） plays a pivotal role in regulating tumor angiogenesis. VEGFR has become a common molecular target which has a potential value in angiogenesis diagnosis and therapy at present. Radionuclide receptor imaging has the advantage of high sensitivity and specificity, by which distribution density of VEGFR and its affinity with its ligand in tumor tissue can be revealed. VEGFR imaging is helpful in diagnosis, staging and detection of recurrence and metastasis of tumor and plays an instructive role in biological therapy of tumor mediated by VEGFR.