用血液微量元素观察右归丸治疗肾阳虚证的实验研究

Experimental investigation of observed that Kidney-yang Reinforeing Bolus cure insufficiency of the kidney-yang by trace element

通过研究右归丸治疗肾阳虚模型的血液微量元素变化，发现与肾阳虚证相对应的血液微量元素经历“平衡→失衡→再平衡”的变化，这不仅说明了血液微量元素能作为正确评价病证转归和药物疗效的一项指标，并且说明了中医中药对证的治疗过程，包涵着中医中药对机体内微量元素平衡体系的整体调控；

In order to study the change of element's concentration when Deficiency of the Kidney-Yang is treated,we make 3 groups of animal (rabbits) model,they are usual group means A group,and the group of Deficiency of the Kidney-Yang means B group that the method of model created is been recommended by the national administration of traditional Chinese medicine and pharmacology in China,and the group of that models of B are cured by Kidney-yang Reinforcing Bolus which is classical prescription treating Kidney-Yang Deficiency. Comparing group A with group B,we find that the latter's concentration of the copper,iron,zinc and the cortisol decrease markedly ( P< 0.05),from clinical symptom and biochemical examining,we diagnose the group B is Insufficiency of the Kidney-Yang.And comparing with group B with group C,the concentration of the copper,iron,zinc,manganese,cadmium,nickel and cortisol increase markedly.It means that deficiency of the kidney-yang has been treated is a process that at first balanceable state was destroyed,and then achieve at new state of equation by treated.The system of the change of element's concentration can be described as `balance-unbalance-rebalance'.This tell us that not only element in blood would help us evaluating rightly prognosis of syndrome and curative effect of herbal medicine,but also it embody that traditional Chinese medicine adjust to balanceable system of element in body when the syndrome has been treated.