乳腺癌肿瘤细胞检测及其临床意义

The tumor cell in breast cancer patients:detection and clinical significance

目前,在部分未见转移的乳腺癌患者中,通过免疫细胞化学和分子生物学的方法能检测到骨髓中的微转移细胞和外周血中的循环肿瘤细胞,而且研究证实检测肿瘤细胞的存在与否,对预后判断和治疗效果监测都有一定的意义,本文就目前所采用的检测微转移细胞和循环肿瘤细胞的方法和它们的临床意义作一简要综述。

With immunocytochemical or molecular assays, disseminated tumor cells （DTC） in the bone marrow or circulating tumor cells （CTC） in the peripheral blood could be detected in some of breast cancer patients without signs of metastasis. And results from recently reported studies suggest the tumor cell may serve as a prognostic marker and be used for assessment of therapeutic response. The paper briefly reviewed the advance of DTC and CTC in the detection methods and its clinical significance.