炎症细胞在儿童重症甲型H1N1流感中的作用及临床意义

The role and clinical significance of inflammatory cells in children with severe type-A H1N1 influenza

目的:探讨急性炎症反应与甲型H1N1流感的关系及其临床意义。方法:12例正常儿童为空白对照组(A组),观察组12例甲型H1N1流感患儿分为B组(6例检测前已使用激素)和C组(6例检测前未使用激素)。结果:1与A组比较,C组患儿单核细胞百分比(MONO%)明显升高,嗜酸性粒细胞计数(EOS)明显降低;B组EOS及EOS%均明显降低(P<0.05)。2与C组比较,B组患儿MONO%下降。结论:甲型H1N1流感重症患儿单核/巨噬细胞系统被激活,激素可抑制其急性炎症反应,本研究对甲型H1N1重症患儿临床治疗有指导价值。

Objective： To study the relationship between acute inflammatory response and type-A H1N1 influenza and its clinical significance.Methods： A group of 12 normal children as the control group,and 12 cases with Type-A H1N1 influenza as the observation group,of which 6 cases had been treated with hormone before inspection（group B）,and 6 cases without using any hormone（group C）.Results： ① Compared with patients in group A,the proportion of monocyte in patients of group C increased significantly,while the proportion of eosinophils decreased obviously.The eosinophils cell count and ratio in group B decreased obviously（P0.05）.② Compared with patients in group C,the mononuclear cell ratio in patients of group B were significantly decreased.Conclusions： The monocyte / macrophage system of the patients with Type-A H1N1 influenza has been activated,and hormone has suppressed the acute inflammatory response,which will provide clinical reference to the treatment of children with severe Type-A H1N1 influenza.