P_0蛋白与周围神经相关疾病的关系及其毒理学意义

Correlation and toxicological significance between myelin protein zero and peripheral nerve disease

P0蛋白是周围神经系统髓鞘上的一种主要结构蛋白,对维持髓鞘结构的稳定性发挥了极其重要的作用。近年来,很多研究表明P0的结构、分布和功能等都已经超出了人们最初的认识,本文就P0蛋白的结构、分布和功能等方面的基本特点及其在神经毒理学研究中的进展做一个简单的概述。

Myelin protein zero（P0） is the major structural element of peripheral myelin that plays a very important role in maintaining the stability of myelin.Recently,many researches find that the structure,distribution and function of P0 have transcended people＇s early understanding.In this review,the basic features of structure,distribution and function of P0 and its current research advances in neurotoxicology are simply summarized.