摘要
铅是广泛存在于环境中的有毒重金属。儿童、孕妇、老年人等不同人群铅暴露和代谢动力学特点迥异,而且铅的暴露和效应与机体多个代谢通路和机制有关。除ALAD、VDR、HFE基因外,新近发现铁代谢相关基因(TF)、氧化应激相关基因(Rac2、GPx1、XDH)也是影响机体铅内暴露水平的相关基因。本文综述了不同人群铅暴露特点、代谢特征及不同人群铅暴露敏感标志物,并对全基因组关联研究(GWAS)在该领域中的应用进行展望。
Lead（Pb） is a toxic heavy metal which exists widely in the environment.Children,pregnant women,the elderly,and other populations,have diverse ways of lead exposure and different toxicokinetics.Moreover,the exposure and effect of lead involve multiple metabolic pathways and mechanisms.Besides ALAD,VDR,HFE genes,the polymorphisms of TF gene and oxidative-stress related genes（Rac2,GPx1,XDH） have been discovered recently to affect lead internal exposure level as well.This review comprehensively describes the characteristics of lead exposure,metabolic characteristics and the lead exposure sensitive markers,of different people groups,and looks forward to the future of the application of Genome-Wide Association Study（GWAS） in this field.
出处
《卫生研究》
CAS
CSCD
北大核心
2010年第5期643-646,共4页
Journal of Hygiene Research
基金
复旦大学研究生科研训练资助计划(No20094110)
复旦大学望道学者项目(No04104)
关键词
铅暴露
生物标志物
易感人群
单核苷酸多态性
环境毒理学
lead poisoning
biomarkers
susceptible population
single nucleotide polymorphism
environmental toxicology
