曲唑酮与丁丙诺啡治疗海洛因依赖者稽延性戒断症状的对照研究

A comparative study of trazodone and buprenornhine in the treatment of protracted withdrawal syndrome in heroin addicts

目的:观察曲唑酮对海洛因依赖者稽延性戒断症状的治疗效果及不良反应。方法:120例海洛因依赖者伴稽延性戒断症状患者随机分为曲唑酮组(n=60例)和丁丙诺啡组(n=60例),均治疗4周,采用稽延性戒断症状评定量表,汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)以及不良反应量表(TESS)分别于治疗前及治疗后第1周末、第2周末、第4周末评定疗效和不良反应。结果:曲唑酮和丁丙诺啡对海洛因稽延性戒断症状均有显著疗效。曲唑酮对焦虑、抑郁症状有明显疗效,丁丙诺啡对焦虑、抑郁症状无明显疗效,两组间差异有显著性。曲唑酮组不良反应明显小于丁丙诺啡组。结论:曲唑酮能有效治疗海洛因依赖者稽延性戒断症状和焦虑、抑郁症状,值得临床推广应用。

Objective：To observe whethere Trazodone could alleviate the protracted withdrawal syndrome in Heroin addict.Methods：120 Patients with protracted withdrawal syndrome in Heroin addict were randomly divided into Trazodone group （n=60）and Buprenorphine group （n=60）for treatment of 4 weeks. All patients were scored through Scale for Protracted Withdrawal Symptoms of Heroin Addicts; HAMA; HAMD;TESS at 1 week,2 weeks,4weeks.Results：Both drugs had marked efficacy in the treatment of protracted withdrawal syndrome.The total scores of HAMA,HAMD of Trazodone group showed significant difference than Buprenorphine group. Trazodone had significantly fewer side effects than Buprenorphine.Conelusion： Trazodone can alleviate the protracted withdrawal syndrome and anxious-depress emotion.This therapy may be spread in clinic.