FADD在喉癌的表达及临床意义

Expression and clinical significance of FADD in carcinoma of larynx

【目的】探讨FADD在喉癌组织中的表达情况及其与临床的关系。【方法】应用免疫组织化学方法检测30例喉鳞状细胞癌组织、20例喉乳头状瘤组织、20例癌旁正常粘膜组织中FADD的表达情况。【结果】(1)FADD在喉鳞状细胞癌组、喉乳头状瘤组及癌旁正常粘膜组中的阳性表达率分别为76.7%、90.0%、95.0%,阳性表达率总体有统计学意义(P<0.05)。(2)FADD的阳性表达率在喉癌I^II期的阳性表达率为95.2%,III^IV期为50.0%,有统计学意义(P<0.05);在高分化癌组织中的阳性表达率为94.4%,中低分化癌组织中的阳性表达率为25.0%,有统计学意义(P<0.05)。FADD阳性表达率与患者性别、年龄、不同临床分型及是否伴有淋巴结转移均无关,无统计学意义(P>0.05)。【结论】FADD在喉癌的发生发展中起着重要的作用,癌组织中FADD的检测对临床预后的判断有一定的指导意义。

【Objective】To explore the clinical significance of FADD in laryngeal squamous carcinoma.【Methods】 The expression of FADD were detected by immunohistochemiscal（IHC） method in 30 cases of larynx squamous cell carcinoma（LSCC）,20 cases of papilloma of larynx and 20 cases of normal adjacent mucosa.【Results】（1） The positive expression rate of FADD in LSCC group,papilloma of larynx group and normal adjacent mucosa group were 76.7%,90.0%,95.0% respectively,the positive expression rate have statistical significance in total（P0.05）.（2） The positive expression rates of FADD were related to cinical stage and with the degree of pathological differentiation,that.In stage I-II group of LSCC was 95.2% and stage of III-IV was 50.0%,with statistical significance（P0.05）.In LSCC of high differentiation was 94.4%,higher than middle-poorly differentiated（25.0%）,with statistical significance（P0.05）.But no relation to sexuality,age,clinical classification and the lymph node metastasis.There were have no statistical significance（P0.05）.【Conclusions】 FADD plays an important role in the occurrence and development of carcinoma of larynx.Determination expression rate of FADD may provide guidance for clinical prognosis.