瑞芬太尼对静脉注射罗库溴铵引起缩肢反应的影响

Remifentanil Prevents Withdrawl Movements Caused by Intravenous Injection of Rocuronium

目的探讨麻醉诱导期间瑞芬太尼预处理对静脉注射罗库溴铵引起的缩肢反应的影响。方法 60例接受腹腔镜胆囊切除术的成年女性患者,随机分为3组,每例患者均注射4.0 mL液体。对照组(GroupA,n=20):静脉注射生理盐水;瑞芬太尼0.5μg/kg预处理组(Group B,n=20);瑞芬太尼1.0μg/kg预处理组(Group C,n=20)。静脉注射瑞芬太尼30 s后,静脉注射依托咪酯0.3 mg/kg。睫毛反射消失后,静脉注射罗库溴铵0.6 mg/kg(速度为0.5 mL/s)。观察病人的缩肢反应程度。结果瑞芬太尼0.5μg/kg和1.0μg/kg预处理组的缩肢反应发生率明显低于对照组。结论 0.5μg/kg和1.0μg/kg的瑞芬太尼预处理,能够预防静脉注射罗库溴铵引起的缩肢反应。

Objective To evaluate the effect of pretreatment of remifentanil on the withdrawl movements due to intravenous injection of rocuronium during anesthetic induction.Methods Sixty adult female patients undergoing elective laparoscopic cholecystectomy were randomly allocated to three groups.Each patient intravenously received one of three solutions of equal volume（4.0 mL）：normal saline（Group A,n=20）,0.5 μg/kg remifentanil（Group B,n=20） or 1.0 μg/kg remifentanil（Group C,n=20）.Thirty seconds after remifentanil administration,anasthesia was induced with 0.3 mg/kg IV etomidate.When eyelash reflex was abolished,0.6 mg/kg IV rocuronium was administered（injection rate of 0.5 mL/s） and the patients＇ withdrawl movements were assessed.Results The incidence of withdrawl movements was significantly lower in both of the remifentanil groups（5% and 0% in Group B and C,respectively） than in the saline group（70%）.Conclusion The pretreatment with 0.5 and 1.0 μg/kg remifentanil of bolus doses could prevent the withdrawl movements caused by rocuronium injection.