肾综合征出血热患者IL-15的动态变化

Dynamic Changes of IL-15 in Patients with Hemorrhage Fever with Renal Syndrome

目的研究不同临床类型肾综合征出血热(HFRS)患者血清IL-15水平的动态变化,以探讨细胞免疫紊乱在HFRS发病机制中的作用。方法采用双抗体夹心ELISA法对32例HFRS患者病程各期和20例健康人血清IL-15水平进行检测。结果 HFRS患者血清IL-15各期均显著高于对照组,病程极期达高峰,与BUN变化相一致,重症患者IL-15在发病早期和极期均显著高于轻症组。结论细胞免疫功能紊乱在HFRS发病机制中,具有重要作用。

Objective To explore the roles of IL-15 in the pathogenesis of HFRS through studying the dynamic changes in patients with hemorrhage fever with renal syndrome（HFRS）.Methods Using double antibody sandwich ELISA method to measure the level of IL-15 in serum samples from 32 patients with HFRS and 20 healthy subjects as control.Results The level of IL-15 in serum of patients with HFRS increased significantly in early stage（101.888±27.289）pg/mL,as the level of controls were（36.677±11.996）pg/mL（P﹤0.01）,came to peak value in extreme stage（181.065±47.282）pg/mL,decreased gradually in polyuric stage,and still were in high level in convalscence stage（106.805±14.406）pg/mL,（P﹤0.01 respectively）.Conclusion IL-15 were involved in the pathogenesis of HFRS as protective factors respectively.Cellular immune played an important role in the pathogenesis of HFRS.