期刊文献+

合成生物学研究进展与应用 被引量:3

下载PDF
导出
摘要 合成生物学作为一门新兴的综合交叉学科,将工程学的设计思想和原理应用到生物学的研究当中。在短短的十年间,合成生物学已经取得了一系列重要的进展。这些成果不仅有助于人们对生命本身的理解和认识,同时也为人类解决诸如能源、环境、医疗、药物生产等问题提供了极大的帮助。本文从合成生物学领域几个成功的研究实例出发,综述合成生物学已经取得的重大成就及其实际应用,并展望合成生物学将给人类社会带来的巨大变化。
作者 张柳燕 王晶
出处 《生物产业技术》 2010年第5期54-59,共6页 Biotechnology & Business
关键词 合成生物学
  • 相关文献

参考文献27

  • 1Gardner TS, Cantor CR, Collins JJ: Construction of a genetic toggle switch in Escherichia coli. Nature, 2000, 403(6767):339-342.
  • 2Elowitz MB, Leibler S: A synthetic oscillatory network of transcriptional regulators. Nature, 2000, 403(6767):335-338.
  • 3Fung E, Wong WW, Suen JK, Bulter T, Lee S-g, Liao JC: A synthetic gene-metabolic oscillator. Nature, 2005, 435(7038): 118-122.
  • 4Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty ]: A fast, robust and tunable synthetic gene oscillator. Nature, 2008, 456(7221 ):516-519.
  • 5Martin VJ, Pitera D J, Withers ST, Newman JD, Keasling JD: Engineering a mevalonate pathway in Escherichia coil for production of terpenoids. Nature Biotechnology, 2003, 21(7):796-802.
  • 6Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J et al: Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature, 2006, 440(7086):940-943.
  • 7Gibson DG, Glass Jl, Lartigue C, Noskov VN, Chuang R-Y, Algire MA, Benders GA, Montague MG, Ma L, Moodie MM et al: Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome. Science , 2010:science. 1190719.
  • 8Friedland AE, Lu TK, Wang X, Shi D, Church G, Collins JJ: Synthetic Gene Networks That Count. Science, 2009, 324(5931 ): 1199-1202.
  • 9Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EPS, Landgraf D, Phillips I, Silver PA: Rational design of memory in eukaryotic ceils. Genes & Development, 2007, 21 ( 18):2271-2276.
  • 10Danino T, Mondragon-Palomino O, Tsimring L, Hasty J: A synchronized quorum of genetic clocks. Nature, 2010, 463(7279):326-330.

同被引文献36

  • 1Mandal M,Boese B,Barrick JE,Winkler WC,Breaker RR.Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria.Cell,2003,113(5): 577-586.
  • 2Ellington AD,Szostak JW.In vitro selection of RNA molecules that bind specific ligands.Nature,1990,346(6287): 818-822.
  • 3Stoltenburg R,Reinemann C,Strehlitz B.SELEX-a (r) evolutionary method to generate high-affinity nucleic acid ligands.Biomol Eng,2007,24(4): 381-403.
  • 4Tuerk C,Gold L.Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.Science,1990,249(4968): 505-510.
  • 5Pfleger BF,Pitera DJ,Smolke CD,Keasling JD.Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes.Nat Biotechnol,2006,24(8): 1027-1032.
  • 6Leloup JC,Goldbeter A.A model for circadian rhythms in Drosophila incorporating the formation of a complex between the PER and TIM proteins.J Biol Rhythms,1998,13(1): 70-87.
  • 7Hasty J,McMillen D,Collins JJ.Engineered gene circuits.Nature,2002,420(6912): 224-230.
  • 8Gardner TS,Cantor CR,Collins JJ.Construction of a genetic toggle switch in Escherichia coli.Nature,2000,403(6767): 339-342.
  • 9Elowitz MB,Leibler S.A synthetic oscillatory network of transcriptional regulators.Nature,2000,403(6767): 335-338.
  • 10Fung E,Wong WW,Suen JK,Bulter T,Lee SG,Liao JC.A synthetic gene-metabolic oscillator.Nature,2005,435 (7038): 118-122.

引证文献3

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部