墨玉县农村维吾尔族牙周炎与代谢综合征相关性的流行病学研究

Epidemiological study on the association of periodontitis with metabolic syndrome in adult Uygur rural residents of Moyu county

目的 探讨慢性牙周炎与代谢综合征患病率的关系.方法 采用分层容量随机抽样方法从墨玉县364村抽取15个村18岁以上维吾尔族成人1 650人,进行问卷调查、血液生化指标检测和相关危险因素调查,口腔检查.依据慢性牙周炎的诊断标准,将调查对象分为牙周炎组和非牙周炎组,其中牙周炎组按其严重程度进一步分为：轻度牙周炎组、中度牙周炎组和重度牙周炎组.代谢综合征采用2005年国际糖尿病联盟（IDF）诊断标准.结果 在资料完整的1415人中有66.0%患慢性牙周炎,275人患有代谢综合征（19.4%）.牙周炎人群中代谢综合征的患病率为23.1%,高于非牙周炎人群12.3%（x2=23.9,P=0.000）,随牙周炎病变程度的加重,其代谢综合征的患病率显著增加,轻度、中度和重度牙周炎组的代谢综合征患病率分别为19.8%、20.8%、27.6%（x2=31.9,P=0.000）.经多因素logistc回归分析提示代谢综合征的患病危险性随牙周炎程度的加重而增加,轻度、中度、重度牙周炎组的OR值分别为1.6、1.7和1.9（P〈0.05或P〈0.01）.结论 维吾尔族代谢综合征的患病率与牙周炎相关,随牙周炎程度的加重而增加.

Objective To investigate the association of prevalence of periodontitis with metabolic syndrome （MS）. Methods Data were analyzed from 1 650 Uygur rural residents in Moyu County. The subjects, aged over 18 years, were sampled randomly from 15 villages out of total 364 villages. Questionnaire, oral examination, and blood biochemical indicators were collected. The subjects were divided into groups with and without periodontitis based on chronic periodontitis diagnostic criteria, and the group with periodontitis was further divided into subgroups, each with mild, moderate, and severe periodontitis respectively. The diagnosis of MS was madeaccording to the definition of the International Diabetes Federation in 2005. Results Among 1 415 subjects whosedata were complete, there were 275 （ 19.4% ） subjects with MS and 934 （66.0%） subjects with periodontitis. The prevalence of MS was higher in the group with periodontitis than that without perionontitis （23.1% vs 12.3%, x2=23.9, P〈0. 001 ）. The prevalence of MS was increased with the grade of periodontitis, being 19.8%, 20.8%,27.6% in the mild, moderate, and severe periodontitis groups, respectively（x2= 31.9, P〈0. 001 ）. Multiple logistic regression analysis showed that the risk of MS increased with the grade of periodontitis, with OR 1. 6, 1.7,1.9, respectively, in the groups with mild, moderate, and severe periodontitis compared with that without perionontitis （ P〈0.05 or P〈0.01 ）. Conclusions The prevalence of MS was related to periodontitis in the Uygur nationality and increased with the grade of periodontitis.