2型糖尿病肾病与亚临床炎症因子的关系

Relationship between Diabetic Nephropathy and Subclinial Inflammatory Factors

目的:探讨亚临床炎症因子血清超敏C反应蛋白(hs-CRP)水平、外周血白细胞(WBC)计数、血浆纤维蛋白原(FIB)水平与2型糖尿病肾病(DN)的关系。方法:我院住院的2型糖尿病(DM)患者506例,分为DN组、非DN组。分别检测、比较2组血清hs-CRP水平、外周血WBC计数、血浆FIB水平及其与DN的关系。结果:DN组血清hs-CRP水平、外周血WBC计数、血浆FIB水平显著高于非DN组(P<0.05),调整了年龄、性别、DM病程、血压、血脂、糖化血红蛋白(HbA1c)、体质指数(BMI)后,血清hs-CRP水平、外周血WBC计数为DN的危险因素(OR分别为1.117和1.127,95%CI分别为1.058～1.180和1.005～1.264)。结论:hs-CRP、FIB、WBC与DN的发生存在密切联系,这些炎症指标可为临床工作中DN的预测和评估病情提供一定的依据。

Objective：To investigate the changes of the sensitivity reactive protein C（hsCRP）,white blood cell（WBC） and fibrinogen（FIB） in patients with diabetic nephropathy（DN）.Methods：The clinical documents of 506 patients with type 2 diabetes were divided into two groups based on with /without DN.The changes of the hsCRP,WBC and FIB,and the relationship between their levels and DN were analyzed in the two groups.Results：Compared to non-DN group,the levels of hsCRP,WBC and FIB were increased obviously in DN group（P 0.05）.In a multiple logistic regression analysis,after adjusting the age,gender,the ascend duration of diabetes,blood pressure,lipid,glycosylated HbA1C and body mass index（BMI）,the levels of WBC and hsCRP were independent risk factors of diabetic nephropathy（OR = 1.117,1.127;95% CI：1.058-1.180,1.005-1.264）.Conclusion：The levels of WBC,FIB and hsCRP are closely related with DN.These subclinical inflammatory index can be used for prognosis and evaluation of DN.