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β淀粉样蛋白在玻璃膜疣形成中的作用 被引量：2

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摘要 β淀粉样蛋白（Aβ）是由淀粉样前体蛋白在体内经过一系列酶水解后形成的.生理情况下,Aβ的生成和降解处于动态平衡中;当机体应激或众多因素刺激使这一平衡破坏时,Aβ会在眼内大量聚集,成为玻璃膜疣的主要致病成分之一.Aβ能与I因子和H因子等免疫因子相互作用,参与补体旁路途径的激活;还能与Cl相互作用,参与补体经典途径的激活,产生级联放大效应,激活下游的免疫分子和炎症分子,参与老年性黄斑变性（AMD）的形成过程.敲除表达Aβ降解酶的基因,能成功建立AMD模型;通过抑制Aβ生成及其作用,有可能成为治疗AMD的新靶点.
作者 叶子 王雨生
机构地区 第四军医大学西京医院眼科全军眼科研究所
出处 《中华眼底病杂志》 CAS CSCD 北大核心 2010年第5期496-499,共4页 Chinese Journal of Ocular Fundus Diseases
基金 国家自然科学基金（30371516,30672291） 教育部留学回国人员科研启动基金（2004）
关键词 淀粉样Β蛋白 黄斑变性/病因学 综述文献
分类号 R774.5 [医药卫生—眼科]
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参考文献38

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同被引文献52

  • 1邹海东,张晳,许迅,汪枫桦,张世杰.上海市静安区曹家渡街道年龄相关性黄斑变性的患病率调查[J].中华眼科杂志,2005,4(1):15-19. 被引量：107
  • 2江伟,邱春亿.年龄相关性黄斑变性(AMD)实验模型的研究进展(英文)[J].国际眼科杂志,2007,7(3):585-589. 被引量：5
  • 3Friedman DS,0"Colmain BJ, Munoz B , et al. Prevalence of age-relatedmacular degeneration in the United States[ J] . Arch Ophthalmol ,2004 ,122:564-572.
  • 4Xu L, Wang S, Li Y, et al. Retinal vascular abnormalities andprevalence of age-related macular degeneration in adult Chinese : theBeijing Eye Study [ J] . Am J Ophthalmol ,2006 ,142 : 688 -689.
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  • 7Age-Related Eye Disease Study Research Group. Risk factors associatedwith age-related macular degeneration. A case-control study in the age-related eye disease study : Age-Related Eye Disease Study. ReportNumber 3 [ J]. Ophthalmology ,2000,107 : 2224-2232.
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中华眼底病杂志
2010年 第5期

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