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结核病患者外周血中iNKT细胞的数量显著降低 被引量：4

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摘要 目的:比较结核病患者和健康对照外周血iNKT细胞数量的差异,分析结核病患者伴发糖尿病对外周血iNKT细胞数量的影响。方法:采集37例结核病患者和12例健康志愿者的静脉血,用特异性抗体anti-Vα24-PE/anti-Vβ11-FITC标记iNKT细胞,流式细胞术(FCM)检测外周血中iNKT细胞的含量。结果:结核病患者和健康对照外周血iNKT细胞的百分含量分别为0.01%(0.24%/0.00%)和0.08%(0.19%/0.00%),差异显著(P<0.01)。伴发糖尿病的结核病患者和非糖尿病的结核病患者iNKT细胞的百分含量分别为0.015%(0.09%/0.00%)和0.01%(0.24%/0.00%),差异无统计学意义(P>0.05)。结论:结核病患者外周血中iNKT细胞数量明显减少,伴发糖尿病对结核病患者外周血iNKT细胞数量没有显著影响。
作者 刘艳华 王心静 曹志红 董梅 佟爱华 程小星
机构地区 解放军第 解放军第
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2010年第10期1017-1019,共3页 Chinese Journal of Cellular and Molecular Immunology
关键词 INKT细胞 结核病 外周血 糖尿病 流式细胞术
分类号 R446.6 [医药卫生—诊断学]
  • 相关文献

参考文献9

  • 1Dorman SE, Chaisson RE. From magic bullets back to the magic mountain: the rise of extensively drug-resistant tuberculosis[J]. Nat med, 2007, 13(3): 295-298.
  • 2刘景华,于力.NKT细胞研究进展[J].细胞与分子免疫学杂志,2008,24(2):194-196. 被引量：18
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二级参考文献20

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共引文献17

同被引文献22

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引证文献4

二级引证文献18

细胞与分子免疫学杂志
2010年 第10期

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