摘要
创伤的大脑损害(TBI ) 在世界上是死亡和病态的一个主要原因。最近的临床的调查和基本研究建议改进 angiogenesis 追随者 TBI 的策略可以提供有希望的机会改进临床的结果和大脑功能的恢复。越来越多的证据显示出那位传播 endothelial 祖先房间(EPC ) 它在外设被识别了血，可以在成年人在病理学、生理的 angiogenesis 起一个重要作用。而且，出色的数据证明 EPC 响应创伤或煽动性的刺激从骨头髓被动员到血循环。在这评论，我们以后为 TBI 的功能的恢复在大脑损害和可能的治疗学的含意的修理讨论了 EPC 的角色。
Traumatic brain injury （TBI） is a major cause of mortality and morbidity in the world. Recent clinical investigations and basic researches suggest that strategies to improve angiogenesis following TBI may provide promising opportunities to improve clinical outcomes and brain functional recovery. More and more evidences show that circulating endothelial progenitor cells （EPCs）, which have been identified in the peripheral blood, may play an important role in the pathologic and physiological anglo-genesis in adults. Moreover, impressive data demonstrate that EPCs are mobilized from bone marrow to blood circula- tion in response to traumatic or inflammatory stimulations. In this review, we discussed the role of EPCs in the repair of brain injury and the possible therapeutic implication for func- tional recovery of TBI in the future.
基金
This work was partially supported by grants from the National Natural Science Foundation of China （No. 30772229） and the Research Fund for the Doctoral Program of Higher Education in China （No. 20070062008）.
