鹦鹉热衣原体基因工程亚单位疫苗免疫羊抗体产生动力曲线

Kinetics curve of antibody responses in ewes immunized with subunit vaccine of genetically engineered Chlamydia psittaci

目的观察鹦鹉热衣原体基因工程亚单位疫苗免疫羊后产生的动力学曲线。方法用不同剂量鹦鹉热衣原体主要外膜蛋白基因工程亚单位疫苗免疫绵羊,免疫前及免疫后不同时间采血检测抗体情况,观察绵羊抗体的产生和变化水平。结果免疫剂量为0.5mg/只颈部肌肉多点注射,具有良好的免疫效果。结论鹦鹉热衣原体基因工程亚单位疫苗免疫剂量为0.5mg/只颈部肌肉多点注射,在绵羊整个妊娠期内具有保护作用。

This study analyzed antibody responses in ewes vaccinated with three different doses of major outer-membrane protein subunit vaccine from genetically engineered Chlamydia psittaci.Sera of ewes were detected before vaccination and at different times post-vaccination.Experimental results indicated that multilocus intramuscular injection in the neck region with dose of 0.5 mg per ewe could stimulate good immune response.