HIV/HCV合并感染HIV母婴阻断效果分析

To analyze the interdiction effect of HIV maternal-neonatal transmission on patient who infects concurrently HIV and HCV

目的探讨以三联高效抗逆转录病毒药物治疗(highly active antiretrorival therapy,HAART)为主的综合措施预防人类免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)合并感染者HIV母婴传播效果。方法给HIV/HCV合并感染的孕妇孕期应用三联高效抗逆转录病毒药物治疗,方案为AZT+3TC+EFV或AZT+3TC+NVP,结合安全分娩和人工喂养预防HIV母婴传播。结果 21例婴儿中有8例年满12月龄行HIV抗体检测结果均阴性,13例年满18月龄行HIV抗体检测结果均阴性,现阶段母婴传播率为零。结论 HIV/HCV合并感染的孕产妇孕期应用三联高效抗逆转录病毒药物治疗为主的综合措施,HIV母婴传播阻断效果与单纯HIV感染母婴阻断效果相比较效果相似。

Objective To investigate the effect of preventing human immunodeficiency virus（ HIV） maternal-neonatal transmission on patient who infects concurrently HIV and hepatitis C virus（ HCV） by using comprehensive measures as trigeminal highly active antiretrorival therapy mainly. Methods To apply trigeminal HAART for pregnant woman who infects concurrently HIV and HCV in gestational period,the plan includes AZT and 3TC and EFV,or AZT and 3TC and NVP,combining safe delivery and artificial feeding prevent HIV maternal-neonatal transmission. Results In twenty-one infants＇HIV antibody testing results,eight ones who are twelve month＇s age are negative,and thirteen ones who are eighteen month＇s age are negative too,the rate of maternal-neonatal transmission is zero at the present stage. Conclusion To compare with the interdiction effect of HIV maternal-neonatal transmission on pregnant woman who infects merely HIV,the patient,who infects concurrently HIV and HCV in gestational period,is similar,by using comprehensive measures as trigeminal HAART mainly.