阿立哌唑和利培酮治疗老年性精神分裂症的对照研究

Comparative study on elderly schizophrenics by aripiprazole and risperidone

目的探讨阿立哌唑对老年性精神分裂症患者的疗效、不良反应及生存质量的影响。方法将80例老年性精神分裂症患者随机分为阿立哌唑组与利培酮组,治疗观察12周。以阳性和阴性症状量表(PANSS)、世界卫生组织生活质量量表(WHQOL-100)、治疗中出现的症状量表(TESS)评定疗效、生存质量及不良反应。结果阿立哌唑组与利培酮组疗效相当,两组患者的PANSS评分均明显减少,差异有显著性(P<0.01);两组间无显著差异(P>0.05)。两组WHQOL-100评分均较治疗前有显著改善(P<0.01),两组间无显著差异(P>0.05)。阿立哌唑组锥体外系反应、心动过速及体重增加等不良反应发生率显著低于利培酮组,差异有显著性(P<0.01)。结论阿立哌唑对老年性精神分裂症有良好的疗效,能有效改善患者的生存质量,且安全性高,依从性好,适合老年性精神分裂症患者使用。

Objective To compare the efficacy,quality of life and safety of aripiprazole to treat elderly schizophrenics. Methods 80 elderly schizophrenic patients were randomly divided into aripiprazole group and risperidonegroup for 12 weeks. The efficacy was measured with Positive and Negative Syndrome Scale for schizophrenia （ PANSS） ,the side effects were assessed by the treatment emergent symptom scale （ TESS） ,the WHO Quality of Life-100 scale（ WHQOL-100） for quality of life. Results By the end of the 12 weeks,the scores of PANSS and WHQOL-100 in two groups changed notably （ P 0. 01） 。There was no significant difference between the two groups （ P 0. 05） 。The occurrence rate of extrayramidal side effects,tachycardia and increased weight in the aripiprazole group was significantly lower than in the rispridone group （ P 0. 01）. Conclusion The results suggest that aripiprazole is effective,safety and good compliance for the treatment of elderly schizophrenics,It can improve the patients,quality of life efficiently,Aripiprazole is beneficial for elderly schizophreni-a.