MIF和MMP-2在宫颈癌中的表达及临床意义

Expression and clinical significance of MIF and MMP-2 in cervical cancer

目的探讨巨噬细胞移动抑制因子(MIF)及基质金属蛋白酶-2(MMP-2)在宫颈癌的表达及临床意义。方法采用免疫组化SP法检测68例宫颈癌组织、24例宫颈上皮内瘤病变(CIN)组织和21例正常宫颈组织(对照组)中MIF及MMP-2的表达,并对宫颈癌组织MIF与MMP-2表达进行相关性分析。结果宫颈癌组MIF和MMP-2阳性表达率显著高于CIN组和对照组;宫颈癌组不同临床分期、组织分化、有无淋巴结转移之间比较,MIF和MMP-2的阳性表达率均有显著性差异(P<0.05),且二者表达强度呈显著正相关(r=0.82,P<0.05)。结论 MIF和MMP-2过表达可能与宫颈癌的发生、发展有关,二者联合检测可作为评估宫颈癌恶性程度、判断预后及指导治疗的重要参考指标。

Objective To explore the expression and clinical significance of macrophage migration inhibitory factor （ MIF） and matrix metalloproteinase-2（ MMP-2） in cervical cancer. Methods SP immunohisto-chemical technique was used to detect the expression of MIF and MMP-2 in 68 cases of cervical cancer,24 cases of cervical intraepithelial neoplasia（ CIN） and 20 cases of normal cervical tissue（ control group）. Correlation was analysed between MIF and MMP-2 expression in cervical cancer tissues. Results The positive rates of MIF and MMP-2 were higher in cervical cancer group than in CIN group and control group （ P 0. 01）. In cervical cancer group,there were also significant differences of MIF and MMP-2 positive rates among the different clinical stages,among the different pathological grades and between the different lymph node involvement （ P 0. 05）. There was positive correlation between the expression of MIF and MMP-2 in cervical cancer tissues. （ P 0. 05）. Conclusion The excessive expression of MIF and MMP-2 is associated with the occurrence and de-velopment of cervical cancer. The combined detection of MIF and MMP-2 may be an important index to evaluate the degree of malignance,judge prognosis and direct treatment of cervical cancer.