期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CXC类趋化因子受体4在口腔鳞状细胞癌中的表达及临床意义 被引量：5

The expression of CXC receptor 4 and its role in human oral squamous cell carcinoma
下载PDF
导出
摘要 目的探讨CXC类趋化因子受体(CXCR)4在口腔鳞状细胞癌(OSCC)组织中的表达及其与临床病理因素之间的关系。方法应用免疫组织化学SP法检测OSCC组织中CXCR4的表达。结果 OSCC组织中CXCR4的阳性表达率明显高于正常对照组。CXCR4的表达与肿瘤的分化程度、TNM分期和淋巴结转移密切相关,而与性别、年龄和肿瘤大小无关。结论 CXCR4的表达可能在OSCC的发生、发展中起着一定的作用。 Objective To investigate the expression of CXC receptor（CXCR） 4 and its role in oral squamous cell carcinoma（OSCC）. Methods SP immunohistochemical method was used to detected the expression of CXCR4 in OSCC. Results There were positive correlations between the expression of CXCR4 and the differentiation,TNM classification,lymph node metastasis of tumor. Conclusion CXCR4 may play a key role in the emergence and development of OSCC.
作者 程伟 童昕 马建民 温波 王芳芳 李岭
机构地区 南京大学附属口腔医院种植科
出处 《国际口腔医学杂志》 CAS 2010年第5期502-503,共2页 International Journal of Stomatology
关键词 口腔鳞状细胞癌 基质细胞衍生因子-1 CXC类趋化因子受体4 oral squamous cell carcinoma stromal cell-derived factor-1 CXC receptor 4
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Takanami I.Overexpression of CCR7 mRNA innonsmall cell lung cancer:Correlation with lymph node metastasis[J].Int J Cancer,2003,105(2):186-189.
  • 2Zlotnik A,Yoshie O.Chemokines:A new classification system and their role in immunity[J].Immunity,2000,12(2):121-127.
  • 3Li YM,Pan Y,Wei Y,et al.Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis[J].Cancer Cell,2004,6(5):459-469.
  • 4Balkwill F.Cancer and the chemokine network[J].Nat Rev Cancer,2004,4 (7):540-550.
  • 5Müller A,Homey B,Soto H,et al.Involvement of chemokine receptors in breast cancer metastasis[J].Nature,2001,410(6824):50-56.
  • 6Kato M,Kitayama J,Kazama S,et al.Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma[J].Breast Cancer Res,2003,5 (5):R144-R150.

同被引文献42

  • 1周英琼,曾思恩,侯巧燕,陆明深,张美艳.P-gp、GST-Л、p53和CD44v6在肺癌中的表达[J].肿瘤防治研究,2005,32(11):699-701. 被引量：2
  • 2崔明,徐海,杨彦.Pokemon蛋白在乳腺癌中的表达及意义[J].临床外科杂志,2007,15(6):399-401. 被引量：23
  • 3陈谦明.口腔粘膜病学[M].第3版.北京:人民卫生出版社,2008:58-68.
  • 4Kabanov AV , Batrakova EV, Alakhov VY. Pluronic block copolymers for overcoming drug resistance in cancer [J]. Adv Drug Deliv Rev, 2002, 54(5) : 759--779.
  • 5Tsuruo T, Naito M, Tomida A, et al. Molecular argeting therapy of cancer:drug resistance, apoptosis and survival sig- nal [J]. Cancer Sci, 2003, 94(1): 15--21.
  • 6Fojo AT , Ueda K, Slamon DJ , et al. Expression of a multi- drug resistance gene in human tumors and tissues [J]. Pro- ceedings of the National Academy of Sciences(USA) , 1987, 84(1) : 265--269.
  • 7Camassei FD ,Arancia G,Cianf riglia M , et al. Nephroblas- toma : muhidrug--resistance P--glyeoprotein expression in tumor cells and intratumoral capillary endotholial cells [J]. Am J ClinPathol, 2002, 117(3) : 484--490.
  • 8Lacueva FJ , Calpena R, Medrano J, et al. Changes in P-- glycoprotein expression in gastril carcinoma with respect to distant gastric mucosa may be influenced by p53 [J]. Cancer, 2000, 89 (1): 21--28.
  • 9Jonker JW, Buitelaar M, Wagenaar E, et al. The breast cancer resistance protein protects against a major chlorophyll --derived dietary phototoxin and protoporphyria [J]. Proc Natl Acad Sci USA, 2002, 99(24): 15649--15654.
  • 10Zhang W, Shannon WD, Duncan J, et al. Expression of drug pathway proteins is independent of tumor type [J]. J Pathol, 2006, 209 (2) :213--219.

引证文献5

二级引证文献13

国际口腔医学杂志
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部