颞下颌关节骨关节病基因治疗的研究进展

Research progress of gene therapy on temporomandibular joint osteoarthrosis

骨关节病是常见的关节退行性疾病,以软骨损伤为特征,常规治疗效果不理想,基因治疗作为新的技术近年来已经开始用于关节病的治疗。颞下颌关节是活动最频繁的滑膜关节之一,出生后即开始发生不断地改建,以适应不同年龄阶段咀嚼功能的需要,其结构与功能对于维持口颌系统的平衡起着重要作用。颞下颌关节虽然体积小,但却承担了相对较大的咀嚼力,因此较其他的大关节更容易发生骨关节病。本文对颞下颌关节骨关节病基因治疗的靶细胞、目的基因和载体等的研究进展作一综述。

Osteoarthrosis is a common degenerative articulation disease,which is characterized by cartilage injury. Conventional treatment of this disease is not satisfactory. Gene therapy becomes a new technique for the treatment of joint diseases in recent years. Temporomandibular joint is one of the most active synovial joints. It is in ongoing remolding after birth,which will meet to the demand of masticatory function at different age stages. The structure and function of this joint are significant to keep the balance of stomatognathic system. Although temporomandibular joint is small in size,it bears relatively heavy masticatory force. So it is more vulnerable to osteoarthrosis than other larger joints. This article is a brief review about the progress of target cells,candidate gene and vectors of gene therapy on temporomandibular joint osteoarthrosis.