摘要
脑动脉粥样硬化是导致脑梗死的主要原因。CD40／CD40L的过度表达会激发免疫和炎症反应，导致粥样斑块内局部炎症细胞浸润，促发斑块破裂，进而发生脑梗死。近年来的研究表明，CIMOL与脑梗死体积和严重程度相关。因此，检测CD40L可作为判断脑梗死严重程度的一项指标，用以指导临床治疗。
Cerebral artery atherosclerosis is the main reason leading to cerebral infarction. CD40/CD40L overexpression will stimulate the immune and inflammatory responses, leading to local inflammatory cell infiltration within the atherosclerotic plaque, triggering plaque rupture, and thus causing cerebral infarction. Studies have suggested that that CD40L is associated with the severity of cerebral infarction. Therefore, clinical detection of CD40L can be used as an indicator for identifying the severity of cerebral infarction to guide clinical treatment.
出处
《国际脑血管病杂志》
北大核心
2010年第8期632-636,共5页
International Journal of Cerebrovascular Diseases
