消食和胃冲剂对小鼠胃肠动力的影响

Effects of Xiaoshihewei Granule on gastrointestinal motility in Kunming mice

目的:研究消食和胃冲剂及其方中各组成药物对小鼠胃肠动力的影响.方法:将消食和胃冲剂及其各组成药味以正交设计法分组,以昆明小鼠为对象,观察各组用药后营养性半固体食物于胃内残留率和小肠推进比,并依正交设计的方法探讨方剂中各药味对小鼠胃肠动力的主次作用和交互作用.结果:消食和胃冲剂中部分组成药物有促进胃排空和小肠推进的作用.各单味药增加胃排空效应的大小为:砂仁>山楂>神曲>枳实,莱菔子作用不明显,茯苓、甘草则作用相反,可见砂仁、山楂、神曲对促进胃排空起主要作用;各单味药增加小肠推进效应的大小为:砂仁>山楂>莱菔子>枳实,茯苓、神曲作用不明显,甘草则作用相反.可见砂仁、山楂、莱菔子对促进小肠推进起主要作用.各组成药物之间存在着广泛的协同作用.结论:消食和胃冲剂中砂仁、山楂、神曲对胃排空有明显的促进作用,砂仁、山楂、莱菔子对小肠推进有明显的促进作用,各味药物之间存在着广泛的协同作用.

AIM：To evaluate the effects of Xiaoshihewei Granule and its each herbal component on gastric emptying and small intestinal propulsion in healthy mice.METHODS：An orthogonal design was used to evaluate the effects of Xiaoshihewei Granule and its each herbal component on gastric emptying and small intestinal propulsion in Kunming mice.The effects of each herbal component on gastrointestinal motility were then compared.RESULTS：Orthogonal analysis showed that Sharen,Shanzha and Shenqu herbs in Xiaoshihewei Granule had significant impact on gastric emptying,and Sharen,Shanzha and Laifuzi herbs had significant impact on small intestinal propulsion in healthy mice.Significant synergistic effects were observed among the various herbal components of Xiaoshihewei Granule.CONCLUSION：Sharen,Shanzha and Shenqu herbs in Xiaoshihewei Granule have significant impact on gastric emptying,while Sharen,Shanzha and Laifuzi herbs have significant impact on small intestinal on in healthy mice.There are significant synergistic effects among the various herbal components of Xiaoshihewei Granule.