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糖尿病肾病的发病机制及治疗进展 被引量:40

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摘要 糖尿病肾病(diabetic nephropathy,DN)是糖尿病(diabetesmellitus,DM)最主要的微血管并发症,也是导致慢性肾衰竭的主要原因之一。DM病程10年以上者约50%并发DN,每年新增终末期肾病中,DN所占比例逐年升高。中华医学会糖尿病学分会于2001年组织的全国各省市自治区近10年的24496例住院DM患者并发症情况的调查报告表明,我国住院DM患者中并发肾脏病变者533.6%。随着社会经济的发展,DM的患病率将不断增加,随之而来DN的发生率也将不断升高,对DN的防治已经成为当前糖尿病和肾病学者们共同面临的重要课题。
作者 李阳
出处 《当代医学》 2010年第26期18-20,共3页 Contemporary Medicine
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参考文献10

  • 1Ceriello A.New insights on oxidative stress and diabetic complications may lead to"causal"antioxidant therapy[J].Diabetes Care,2003,26(5):1589-1596.
  • 2Body-White J,Williams JC.Effect of cross-linking on matrixperme ability:a model for AGE2 modified basementmembranes[J].Kidney Int,1996,46(3):348-353.
  • 3Karamanos B,Porta M,Songini M,et al.Different risk factors of microangiopathy in patients with type 1 diabetes mellitus of shorter long duration:the Eurodiab IDDM Comp lications Study[J].Diabetologia,2000,43(3):348-355.
  • 4Barroso LC,Herrera ND,Hueros JC.et al.lncidence of cardiovascular disease and vajidity of equations of coronary risk in diabeticpatients with metabolic syndrome[J].Med Clin(Barc),2007,128(14):529-535.
  • 5No authors listed.Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes:UKFDS 391UK Prospective Diabetes Study Group[J],BMJ,1998,317(7160):713-720.
  • 6Dai C,Stolz DB,Bastacky SI,et al.Essential role of integrinlinkedkinase in podocyte biology:bridging the Integrin and slit diaphragm signaling[J].J Am Soc Nephrol,2006.17(8):2164-2175.
  • 7Kim SI,Kwak JH.Zachariah M.et al.TGF2-activated kinase 1 andTAK 1-binding protein 1 cooperate to mediate TGF212 inducedMKK32p38 MAPK activation and stimulation of type Ⅰ collagen[J].AmJ Physiol Renal Physiol,2007,292(5):1471-1478.
  • 8Huang CC,J inn YG,Shyi JS,et al.Insulin and heparin suppress peroxide production in diabetic ratglomeruli stimulated with low-density Lipoprotein[J].Kidney Int,2001,59(1):124-130.
  • 9Park YS,Gudarro C,Kim Y,et al.Lovastin reduces glomerular macrophage influx and expression of monocyte chemoattractant protein21 mRNA in nephritic rats[J].Am J Kidney Dis,1998,31(1):190-197.
  • 10Ritz E,Ogata H,Orth SR.Smoking:a factor promoting onset and progression of diabetic nephropathy[J].Diabetes Metab,2000.26(14):54-63.

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