经鼻持续气道正压通气(NCPAP)治疗早产儿反复呼吸暂停的临床研究

目的探讨经鼻持续气道正压通气(NCPAP)治疗早产儿反复呼吸暂停的有效性及临床价值。方法将62例反复呼吸暂停的早产儿随机分成NCPAP治疗组和对照组各31例,治疗组在综合治疗的基础上给予NCPAP治疗,对照组则在综合治疗的基础上给予氨茶碱治疗;比较两组患儿治疗前后的肺功能变化、临床疗效。结果 NCPAP治疗组患儿在治疗4h时动脉血氧分压(PaO2)及动脉二氧化碳(PaCO2)出现改变,氧合指数(OI)显著下降,与治疗前对比差异有统计学意义(P<0.05),在治疗24h后,PaO2、PaCO2和OI等指标,与开始治疗时比较,差异有统计学意义(P<0.05);治疗组中显效21例,有效6例,总有效27例;对照组中显效12例,有效5例,总有效17例,二组治疗效果经卡方检验,差异有统计学意义(P<0.05)。结论 NCPAP治疗早产儿反复呼吸暂停,能更好改善肺的氧合功能,疗效显著,与传统的治疗方法相比,具有更多的优越性,值得在临床中进一步研究和推广应用。

Objective TO investigate the effectiveness and clinical value of nasal continuous positive airway pressure （NCPAP） treatment of apnea in premature children repeated.Methods 62 patients with recurrent apnea in premature children were randomly divided into NCPAP treatment group and control group 31 cases.The treatment group on the basis of comprehensive treatment for NCPAP treatment;Control group on the basis of the comprehensive treatment given aminophylline treatment.and compare the two groups of lung function in children before and after treatment.the clinical efficacy.Results NCPAP treatment group children in the treatment of 4h.arterial oxygen pressure （PaO2） and arterial carbon dioxide （PaCO2） appear to change.Oxygenation index （OI） decreased significantly.compared with that before treatment.the difference was significant （P0.05）.after 24h of treatment.PaO2.PaCO2 and OI and other indicators.and the beginning of treatment compared.the difference was significant （P 0.05）;treatment group.21 cases markedly.effective in 6 cases.27 cases of the total effective;Control group.12 cases markedly effective in 5 cases.the total effective in 17 cases.after treatment the two groups Chi-square test.the difference was significant （P0.05）.Conclusion NCPAP treatment of recurrent apnea in premature children.Oxygenation to better lung function improved.significant effect.compared with the traditional treatment methods.has more advantages.worthy of further study in clinical and application.